Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis.

Ibrahim H Yaseen, Peter N Monk, Lynda J Partridge

Biochemical Society transactions 2017 Apr 15

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Tetraspanin 2 (Tspan2) is one of the less well-characterised members of the tetraspanin superfamily, and its precise function in different human tissue types remains to be explored. Initial studies have highlighted its possible association in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. In this review, we discuss the available evidence for the potential role of Tspan2 and introduce possible strategies for disease targeting. © 2017 The Author(s).

Citation

Ibrahim H Yaseen, Peter N Monk, Lynda J Partridge. Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis. Biochemical Society transactions. 2017 Apr 15;45(2):465-475