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Among all new cancer cases in 2012, on average, 15.4% were caused by Helicobacter pylori or oncoviruses, including Epstein-Barr virus, human papillomavirus, hepatitis B virus, hepatitis C viruses, Kaposi sarcoma-associated herpesvirus and human T-lymphotropic virus. These pathogens encode a variety of non-coding RNAs, which are important cofactors for oncogenesis. In this review, we focus on recent developments in the study of long and small non-protein-coding RNAs, including microRNAs, of oncogenic pathogens, and discuss their mechanisms of action in the multiple steps of oncogenesis.


Noriyuki Yoshida, Tominori Kimura. Pathogen-associated regulatory non-coding RNAs and oncogenesis. Frontiers in bioscience (Landmark edition). 2017 Jun 01;22:1599-1621

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PMID: 28410134

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