Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H.

Total syntheses of three different lamellarins have been accomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole ring. The striking features of this synthesis are the use of PEG-400 as a green solvent for the (3 + 2) annulation reaction and multiple catalytic reactions with excellent overall yield. The present route also enables the synthesis of various lamellarin analogues devoid of a B ring.

Citation

Dhanaji M Lade, Amit B Pawar, Prathama S Mainkar, Srivari Chandrasekhar. Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H. The Journal of organic chemistry. 2017 May 05;82(9):4998-5004

PMID: 28421766

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