The differentiated and conserved roles of Swi5-Sfr1 in homologous recombination.

Bilge Argunhan, Yasuto Murayama, Hiroshi Iwasaki

FEBS letters 2017 Jul

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Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5-Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species. © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

Citation

Bilge Argunhan, Yasuto Murayama, Hiroshi Iwasaki. The differentiated and conserved roles of Swi5-Sfr1 in homologous recombination. FEBS letters. 2017 Jul;591(14):2035-2047