Hb Moncloa: A new variant of haemoglobin that interferes in the quantification of Hb A1c.

María Josefa Torrejón, N Valentina Ortíz-Cabrera, Jorge M Nieto, Fernando-Ataúlfo González Fernández, Ana Villegas, Rafael Martínez, Paloma Ropero

Clinical biochemistry 2017 Jun

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In most routine laboratories in Spain, the commonly used method for evaluating HbA1c is ion-exchange high performance liquid chromatography (HPLC). The presence of a variant of Hb may interfere with the quantification of HbA1c. Here, we report a novel haemoglobin variant, named Hb Moncloa, which was found during a routine health check at the Hospital Clínico San Carlos in Moncloa (Madrid), Spain. Molecular characterization of β gene identified a novel transversion mutation [β80(EF4)Asn>Ser; HBB:c.242A>G]. When there is no correlation between clinical, glycemic status and glycated haemoglobin of the patient, the chromatogram of HbA1c should be carefully checked to detect the possible presence of variants that cause interference in their measurement. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Citation

María Josefa Torrejón, N Valentina Ortíz-Cabrera, Jorge M Nieto, Fernando-Ataúlfo González Fernández, Ana Villegas, Rafael Martínez, Paloma Ropero. Hb Moncloa: A new variant of haemoglobin that interferes in the quantification of Hb A1c. Clinical biochemistry. 2017 Jun;50(9):521-524