Xiaoming Zhou, Balamurugan Packialakshmi, Yao Xiao, Saule Nurmukhambetova, Jason R Lees
Cellular immunology 2017 JulRecent demonstrations of exacerbation of experimental autoimmune encephalomyelitis (EAE) by high salt diets prompted us to study whether EAE stimulated Na absorption by the renal cortex, a primary regulatory site for Na balance, even under a normal NaCl diet. We found that as EAE progressed from mild to severe symptoms, there were parallel increases in the protein abundance of NHE3 and αENaC and the Na,K-ATPase activity with an affiliated elevation of its β1-subunit protein. These effects are associated with increases in the protein levels of the well-known regulators SGK1 and scaffold NHERF2, and phosphorylation of ERK1/2. These effects of EAE could not be explained by reduction in water or food intake. We conclude that EAE progression is associated with up-regulation of major Na transporters, which is most likely driven by increased expression of SGK1 and NHERF2 and activation of ERK1/2. These data suggest that EAE progression increases Na absorption by the renal cortex. Copyright © 2017. Published by Elsevier Inc.
Xiaoming Zhou, Balamurugan Packialakshmi, Yao Xiao, Saule Nurmukhambetova, Jason R Lees. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet. Cellular immunology. 2017 Jul;317:18-25
PMID: 28438314
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