Two new antimalarial quassinoid derivatives from the stems of Brucea javanica.

Parinuch Chumkaew, Jaraslak Pechwang, Theera Srisawat

Journal of natural medicines 2017 Jul

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Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3-8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC50 values of 1.41 and 1.06 μM, respectively.

Citation

Parinuch Chumkaew, Jaraslak Pechwang, Theera Srisawat. Two new antimalarial quassinoid derivatives from the stems of Brucea javanica. Journal of natural medicines. 2017 Jul;71(3):570-573