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    Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.


    Martin Lee, Kevin Rey, Katrina Besler, Christine Wang, Jonathan Choy. Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase. Results and problems in cell differentiation. 2017;62:181-207

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    PMID: 28455710

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