Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies.

Shweta Bhagat, Minhajul Arfeen, Legesse Adane, Savita Singh, Prati Pal Singh, Asit K Chakraborti, Prasad V Bharatam

European journal of medicinal chemistry 2017 Jul 28

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Guanylthiourea (GTU) derivatives were identified as possible anti-malarial agents, recently, using in vitro studies on Plasmodium falciparum. This article gives an account of the in vivo anti-malarial activity of GTU derivatives against experimental rodent malaria. A total of 20 synthesized GTU derivatives were evaluated for in vivo antimalarial activity, out of which six showed encouraging results; one compound appeared to have curative potential. Molecular docking and molecular dynamics analysis were carried out to understand the molecular level interactions. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Citation

Shweta Bhagat, Minhajul Arfeen, Legesse Adane, Savita Singh, Prati Pal Singh, Asit K Chakraborti, Prasad V Bharatam. Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies. European journal of medicinal chemistry. 2017 Jul 28;135:339-348