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In P. falciparum, antioxidant proteins of the glutathione and thioredoxin systems are compartmentalized. Some subcellular compartments have only a partial complement of these proteins. This lack of key anti-oxidant proteins in certain sub-cellular compartments might be compensated by functional complementation between these systems. By assessing the cross-talk between these systems, we show for the first time, that the glutathione system can reduce thioredoxins that are poor substrates for thioredoxin reductase (Thioredoxin-like protein 1 and Thioredoxin 2) and thioredoxins that lack access to thioredoxin reductase (Thioredoxin 2). Our data suggests that crosstalk between the glutathione and thioredoxin systems does exist; this could compensate for the absence of certain antioxidant proteins from key subcellular compartments. Copyright © 2017 Elsevier Inc. All rights reserved.


Rahul Chaudhari, Shobhona Sharma, Swati Patankar. Glutathione and thioredoxin systems of the malaria parasite Plasmodium falciparum: Partners in crime? Biochemical and biophysical research communications. 2017 Jun 17;488(1):95-100

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PMID: 28479253

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