Insights on Heme Synthesis in the Malaria Parasite.

Viswanathan A Nagaraj, Govindarajan Padmanaban

Trends in parasitology 2017 Aug

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The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme pool through multiple back-up mechanisms. Copyright © 2017 Elsevier Ltd. All rights reserved.