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A model of a controlled conversion of polysaccharide Vi-antigen of S. typhi into zwitterionic antigen is proposed. The immunological properties of modifications of this antigen conjugated to a protein support were studied.

Citation

A V Kolesnikov, A V Kozyr, A K Ryabko, I G Shemyakin, I A Dyatlov. Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide. Doklady. Biochemistry and biophysics. 2017 Mar;473(1):141-144

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PMID: 28510135

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