Cell-sized mechanosensitive and biosensing compartment programmed with DNA.

The bottom-up construction of cell-sized compartments programmed with DNA that are capable of sensing the chemical and physical environment remains challenging in synthetic cell engineering. Here, we construct mechanosensitive liposomes with biosensing capability by expressing the E. coli channel MscL and a calcium biosensor using cell-free expression.

Citation

Sagardip Majumder, Jonathan Garamella, Ying-Lin Wang, Maxwell DeNies, Vincent Noireaux, Allen P Liu. Cell-sized mechanosensitive and biosensing compartment programmed with DNA. Chemical communications (Cambridge, England). 2017 Jun 29;53(53):7349-7352

PMID: 28524182

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