The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.

Cytoglobin (CYGB), a member of the globin family, is thought to protect cells from reactive oxygen and nitrogen species and deal with hypoxic conditions and oxidative stress. However, its molecular mechanisms of action are not clearly understood. Through immunoprecipitation combined with a two-dimensional electrophoresis-mass spectrometry assay, we identified a CYGB interactor: aldo-keto reductase family 7 member A2 (AKR7A2). The interaction was further confirmed using yeast two-hybrid and co-immunoprecipitation assays. Our results show that AKR7A2 physically interacts with CYGB.

Citation

Xin Li, Shanshan Zou, Zhen Li, Gaotai Cai, Bohong Chen, Ping Wang, Wenqi Dong. The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner. Cellular & molecular biology letters. 2016;21:25

Mesh Tags

Substances

PMID: 28536627

search → result