Multidisciplinary Management of Mycosis Fungoides/Sézary Syndrome.

Sara Berg, Jennifer Villasenor-Park, Paul Haun, Ellen J Kim

Current hematologic malignancy reports 2017 Jun

filter terms:

Diagnosis and management of mycosis fungoides and Sézary syndrome (MF/SS) require accurate clinicopathological correlation and a multidisciplinary approach. We reviewed major advances in the field regarding diagnostic and prognostic tools as well as skin-directed therapies (SDTs) and systemic agents for MF/SS published in the past 2 years. Improved technology (T-cell receptor high-throughput sequencing) and increased multicenter collaboration (Cutaneous Lymphoma International Consortium) have led to diagnostic/prognostic advances. Concurrently, numerous genomic studies have enhanced understanding of disease pathogenesis. Advances in SDTs include topical resiquimod, a novel potent Toll-like receptor (TLR) agonist; consensus CTCL phototherapy guidelines; and use of low-dose radiation therapy. Novel systemic therapies for advanced disease of note include targeted antibody drug conjugates (brentuximab vedotin), immune checkpoint inhibitors, and allogeneic hematopoietic stem cell transplantation (HSCT). Our "toolbox" to diagnose and treat the spectrum of MF/SS continues to expand. Further characterization of genomic data going forward will enable a rational approach to selecting and combining therapies to improve patient care.

Citation

Sara Berg, Jennifer Villasenor-Park, Paul Haun, Ellen J Kim. Multidisciplinary Management of Mycosis Fungoides/Sézary Syndrome. Current hematologic malignancy reports. 2017 Jun;12(3):234-243