The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children.

Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

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Shu Qing Liu, Xiao Yan Tao, Peng Cheng Yu, Chun Qiu Jin, Hong Jie Yu, Mei Shun Chen, Wu Yang Zhu. The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children. Biomedical and environmental sciences : BES. 2017 May;30(5):373-375

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PMID: 28549493

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