Lignans from the Roots of Taxus wallichiana and Their α-Glucosidase Inhibitory Activities.

Phu H Dang, Hai X Nguyen, Hanh H T Nguyen, Thai D Vo, Tho H Le, Trong H N Phan, Mai T T Nguyen, Nhan T Nguyen

Journal of natural products 2017 Jun 23

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From an EtOAc-soluble extract of the roots of Taxus wallichiana, six new (1-6) and 11 known lignans were isolated. The structures of the new compounds were elucidated based on interpretation of spectroscopic data. (+)-7'-epi-Tsugacetal (1) is a rare aryltetralin-type lignan having a cis-orientation of H-7' and H-8'. Compounds 3-6 were identified as the first naturally occurring tetrahydrofuranoid lignans having a cis-orientation of H-7 and H-8. All tested compounds were found to possess α-glucosidase inhibitory activity, with formosanol (9) showing the most potent effect with an IC50 value of 35.3 μM.

Citation

Phu H Dang, Hai X Nguyen, Hanh H T Nguyen, Thai D Vo, Tho H Le, Trong H N Phan, Mai T T Nguyen, Nhan T Nguyen. Lignans from the Roots of Taxus wallichiana and Their α-Glucosidase Inhibitory Activities. Journal of natural products. 2017 Jun 23;80(6):1876-1882