A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium.

A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

Citation

Damien Hall. A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium. Biophysical chemistry. 2017 Sep;228:10-16

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PMID: 28628895

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