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    Cutaneous and superficial soft tissue spindle cell proliferations with CD34 expression represent a unique heterogeneous group of lesions. They can pose diagnostic challenges for unaware pathologists in their daily practice. - To review selected entities of CD34+ spindle cell proliferations in the skin and superficial soft tissue. The effective diagnostic approaches using clinical, histopathologic, and immunophenotypical findings are discussed within a broad spectrum of differential diagnosis. - All information used in the article is obtained from published literature by PubMed search and Internet-based search engines. The authors' collective experience and real-life examples are also used. - Spindle cell proliferations with CD34 positivity can be worked up to a definitive diagnosis by using clinical, histopathologic, and immunophenotypical findings. Familiarity with these entities helps pathologists make the accurate diagnosis.

    Citation

    Hongyu Yang, Limin Yu. Cutaneous and Superficial Soft Tissue CD34+ Spindle Cell Proliferation. Archives of pathology & laboratory medicine. 2017 Aug;141(8):1092-1100

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    PMID: 28639855

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