Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.


Mona Khalaj, Christopher Y Park. snoRNAs contribute to myeloid leukaemogenesis. Nature cell biology. 2017 Jun 29;19(7):758-760

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 28659642

View Full Text