The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy.

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework.

Citation

J C Fox, R E Gilligan, A K Pitts, H R Bennett, M J Gaunt. The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy. Chemical science. 2016 Apr 21;7(4):2706-2710

PMID: 28660044

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