Biophysical regulation of early limb bud morphogenesis.

The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early limb bud morphogenesis. In particular, I discuss the influence of mesenchymal cohesion and physical properties that might contribute to phase separation of the bud from the lateral plate, the possibility that the early dorsoventral limb bud axis is moulded by the surface ectoderm, and endogenous electric fields that might contribute to oriented cell movements which generate the early limb bud. A combination of quantitative biophysical experimentation and modelling will likely advance this field. Copyright © 2017 Elsevier Inc. All rights reserved.

Citation

Sevan Hopyan. Biophysical regulation of early limb bud morphogenesis. Developmental biology. 2017 Sep 15;429(2):429-433

Mesh Tags

PMID: 28669818

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