CD8+ mycosis fungoides: A low-grade lymphoproliferative disorder.

The prognosis of the CD8+ subtype of mycosis fungoides (MF) is controversial. Although most authors believe that determining the presence of this cell surface antigen has no prognostic value, others have observed a more indolent course for CD8+ MF compared with CD4+ MF. To review the cases of CD8+ MF in the pediatric and adult populations seen at our institution. This is a retrospective review of clinical and pathologic data. Age, stage at presentation, and outcomes of patients at our institution were compared with those of 2 large MF cohorts that predominantly were CD4+ from the relevant literature. Sixty-seven patients of a median age of 46 years were included. A higher frequency of early-stage disease was observed for CD8+ MF patients at diagnosis when compared with other cohorts, including 31 (47%) patients with stage IA, 33 (50%) with stage IB, and 2 (3%) with stage IIB (P = .001, P = .001, and P = .002, respectively). With a median follow-up (5.5 years, range 0.2-21 years) similar to other cohorts, a higher rate of complete remission was achieved (65.5%, P = .001), and a lower rate of progression was observed (P = .004). This is a retrospective review. Our experience with CD8+ MF confirms a more indolent course of disease with this MF variant. Our results warrant a conservative treatment approach limited to skin-directed therapies and observation in most patients. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Citation

Maria Estela Martinez-Escala, Robert W Kantor, Ahuva Cices, Xiaolong A Zhou, Jason B Kaplan, Barbara Pro, Jaehyuk Choi, Joan Guitart. CD8+ mycosis fungoides: A low-grade lymphoproliferative disorder. Journal of the American Academy of Dermatology. 2017 Sep;77(3):489-496

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PMID: 28676328

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