Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors.

D S Lebedev, I A Ivanov, E V Kryukova, V G Starkov, V I Tsetlin, Yu N Utkin

Doklady. Biochemistry and biophysics 2017 May

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Compounds activating γ-aminobutyric acid type A receptor were isolated from the toad Bufo bufo veno m as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.

Citation

D S Lebedev, I A Ivanov, E V Kryukova, V G Starkov, V I Tsetlin, Yu N Utkin. Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors. Doklady. Biochemistry and biophysics. 2017 May;474(1):178-182