Highly Selective Artificial Potassium Ion Channels Constructed from Pore-Containing Helical Oligomers.

Potassium ion channels specifically transport K+ ions over Na+ ions across a cell membrane. A queue of four binding sites in the K+ channel pore plays significant roles during highly selective conduction. A kind of aromatic helical oligomer was synthesized that can selectively bind K+ over Na+ . By aromatic stacking of helical oligomers, a type of artificial K+ channels with contiguous K+ binding sites was constructed. Such artificial channels exhibited exceptionally high K+ /Na+ selectivity ratios during transmembrane ion conduction. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Chao Lang, Xiaoli Deng, Feihu Yang, Bing Yang, Wei Wang, Shuaiwei Qi, Xin Zhang, Chenyang Zhang, Zeyuan Dong, Junqiu Liu. Highly Selective Artificial Potassium Ion Channels Constructed from Pore-Containing Helical Oligomers. Angewandte Chemie (International ed. in English). 2017 Oct 02;56(41):12668-12671

PMID: 28782278

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