New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.

Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.

Citation

Jerome Gouge, Alessandro Vannini. New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer. Transcription. 2018;9(1):61-66

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PMID: 28854119

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