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    A new, direct, and diastereoselective synthesis of activated 2,3,4,6-tetrasubstituted tetrahydro-2H-pyrans is described. In this reaction, iron(III) catalyzed an SN2'-Prins cyclization tandem process leading to the creation of three new stereocenters in one single step. These activated tetrahydro-2H-pyran units are easily derivatizable through CuAAC conjugations in order to generate multifunctionalized complex molecules. DFT calculations support the in situ SN2' reaction as a preliminary step in the Prins cyclization.


    Jimena Scoccia, Sixto J Pérez, Victoria Sinka, Daniel A Cruz, Juan M López-Soria, Israel Fernández, Víctor S Martín, Pedro O Miranda, Juan I Padrón. Direct Access to 2,3,4,6-Tetrasubstituted Tetrahydro-2H-pyrans via Tandem SN2'-Prins Cyclization. Organic letters. 2017 Sep 15;19(18):4834-4837

    PMID: 28858515

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