Loss of CD45 expression at relapse of acute myeloid leukemia.

Katsuya Yamamoto, Kimikazu Yakushijin, Keiji Kurata, Yu Mizutani, Yumiko Inui, Kiyoaki Uryu, Shinichiro Kawamoto, Takeshi Sugimoto, Hiroshi Matsuoka, Hironobu Minami

[Rinsho ketsueki] The Japanese journal of clinical hematology 2017

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A 49-year-old female was initially diagnosed with acute myeloid leukemia (AML) M4 with a CD45＋CD13＋CD33＋CD34-HLA-DR＋ immunophenotype. She underwent allogeneic bone marrow transplantation, but the disease recurred. The bone marrow was infiltrated with 87.0% blasts negative for myeloperoxidase (MPO) staining. Immunophenotyping by flow cytometry identified the presence of a CD45-negative blast population. These blasts exhibited a CD13＋CD33＋CD19-CD10-CD34-HLA-DR- immunophenotype. The lack of CD45 expression is often observed in B-cell acute lymphoblastic leukemia, whereas CD45-negative AML is extremely rare; only one older male with AML-M0 has been reported. In the present case, the CD45-negative blasts had an MPO-CD13＋CD33＋ phenotype, which is similar to AML-M0.

Citation

Katsuya Yamamoto, Kimikazu Yakushijin, Keiji Kurata, Yu Mizutani, Yumiko Inui, Kiyoaki Uryu, Shinichiro Kawamoto, Takeshi Sugimoto, Hiroshi Matsuoka, Hironobu Minami. Loss of CD45 expression at relapse of acute myeloid leukemia. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2017;58(8):938-941