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A 49-year-old female was initially diagnosed with acute myeloid leukemia (AML) M4 with a CD45+CD13+CD33+CD34-HLA-DR+ immunophenotype. She underwent allogeneic bone marrow transplantation, but the disease recurred. The bone marrow was infiltrated with 87.0% blasts negative for myeloperoxidase (MPO) staining. Immunophenotyping by flow cytometry identified the presence of a CD45-negative blast population. These blasts exhibited a CD13+CD33+CD19-CD10-CD34-HLA-DR- immunophenotype. The lack of CD45 expression is often observed in B-cell acute lymphoblastic leukemia, whereas CD45-negative AML is extremely rare; only one older male with AML-M0 has been reported. In the present case, the CD45-negative blasts had an MPO-CD13+CD33+ phenotype, which is similar to AML-M0.


Katsuya Yamamoto, Kimikazu Yakushijin, Keiji Kurata, Yu Mizutani, Yumiko Inui, Kiyoaki Uryu, Shinichiro Kawamoto, Takeshi Sugimoto, Hiroshi Matsuoka, Hironobu Minami. Loss of CD45 expression at relapse of acute myeloid leukemia. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2017;58(8):938-941

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PMID: 28883278

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