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    N-Substituted azaindoles have been discovered as pan-PIM kinase inhibitors. Initial SAR, early ADME and PK/PD data of a series of compounds is described and led to the identification of promising pan-PIM inhibitors which validated our interest in the 7-azaindole scaffold and led us to pursue the identification of a clinical candidate. Copyright © 2017 Elsevier Ltd. All rights reserved.

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    Claude Barberis, Neil Moorcroft, James Pribish, Elina Tserlin, Alexandre Gross, Mark Czekaj, Matthieu Barrague, Paul Erdman, Tahir Majid, Joseph Batchelor, Mikhail Levit, Andrew Hebert, Liduo Shen, Sandra Moreno-Mazza, Anlai Wang. Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorganic & medicinal chemistry letters. 2017 Oct 15;27(20):4735-4740

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    PMID: 28927793

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