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Nitric oxide (NO) plays a key role in the development of peptic ulcer disease (PUD). Conversely, the gastric pathogen Helicobacter pylori colonizes the human stomach and contributes to the development of non-ulcer dyspepsia (NUD) and PUD. But, the underlying relation between molecular NO in exhaled breath and H. pylori associated NUD and PUD largely remains unknown. Here, we explored that the excretion kinetics of NO profiles in exhaled breath are markedly altered for H. pylori infected NUD and PUD subjects. In our observations, PUD exhibited considerably higher enrichments of NO in exhaled breath compared to NUD, thus unveiling a potential link of exhaled NO with ulcer and non-ulcer complications. Our findings therefore suggest that molecular NO in exhaled breath could be used as a potential biomarker for non-invasive diagnosis and selective classification of NUD from PUD. Our observations also illuminate that alterations of NO in the gastric environment can play an important role in the pathogenesis of peptic ulcer and thus may open a new strategy for precise evolution of the actual disease state in a more better and robust way without any endoscopic biopsy test, even after the eradication of H. pylori infection. © 2017 IOP Publishing Ltd.


Suman Som, Gourab Dutta Banik, Abhijit Maity, Sujit Chaudhuri, Manik Pradhan. Exhaled nitric oxide as a potential marker for detecting non-ulcer dyspepsia and peptic ulcer disease. Journal of breath research. 2017 Sep 26

PMID: 28947681

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