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    In this paper, we present and analyze an SEIR Zika epidemic model. Firstly, we investigate the model with constant controls. The steady states of the model is found to be locally and globally asymptotically stable. Thereafter, we incorporate time dependent controls into the model in order to investigate the optimal effects of bednets, treatments of infective and spray of insecticides on the disease spread. Furthermore, we used Pontryagin's Maximum Principle to determine the necessary conditions for effective control of the disease. Also, the numerical results were presented.


    Ebenezer Bonyah, Muhammad Altaf Khan, K O Okosun, Saeed Islam. A theoretical model for Zika virus transmission. PloS one. 2017;12(10):e0185540

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    PMID: 28977007

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