A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.

Georges Mer, Maria Victoria Botuyan

Structure (London, England : 1993) 2017 Oct 03

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Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1. Copyright © 2017 Elsevier Ltd. All rights reserved.

Citation

Georges Mer, Maria Victoria Botuyan. A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction. Structure (London, England : 1993). 2017 Oct 03;25(10):1471-1472

PMID: 28978405

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