Pravastatin for prevention of HELLP syndrome: A case report.

Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. The first pregnancy necessitated termination of pregnancy at gestational age (GA) 20+5 for HELLP. Intrauterine fetal death at GA 22+5 occurred in the second pregnancy, whilst on temporizing management of HELLP. Severe, recurrent early-onset HELLP syndrome. In her fourth pregnancy, pravastatin was commenced at GA 13. The course of pregnancy was uncomplicated, and a healthy, appropriate for gestational age fetus was delivered at term. Pravastatin may be effective in prevention of HELLP. The hepatic uptake may be of particular advantage.

Citation

Lucia Anna Otten, Katrin van der Ven, Marietta Kühr, Ulrich Gembruch, Waltraut Maria Merz. Pravastatin for prevention of HELLP syndrome: A case report. Medicine. 2017 Oct;96(42):e8229

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PMID: 29049209

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