Cisplatin-loaded, Sialyl Lewis X-Modified Liposomes: Drug Release, Biodistribution and Antitumor Efficacy.

Shuichi Kishimoto, Nobuhito Fujitani, Takanori Ohnishi, Hiroki Aoki, Ryosuke Suzuki, Shoji Fukushima

Anticancer research 2017 Nov

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The aim of this study was to evaluate the characteristics of two cisplatin (CDDP)-loaded, sialyl Lewis X-modified liposomes (CDDP-SLX-LIP) with different particle size. Each had the same lipid composition and CDDP concentration, but a different drug-to-lipid ratio. The amount of platinum in the filtrates was determined by the ICP method. The antitumor effect was assessed using rats bearing MRMT-1 tumor. CDDP release was faster from the larger liposome formulation (L-LIP) than from the smaller one (S-LIP). Treatment with the two CDDP-SLX-LIPs resulted in comparable antitumor effects without obvious side-effects, but treatment with CDDP solution resulted in significant weight loss and an elevated BUN. Tumor accumulation of CDDP-SLX-LIP was clearly greater than that of CDDP solution and accumulation of S-LIP was greater than that of L-LIP. CDDP-SLX-LIP exhibited antitumor effects depending on their release behavior and tumor accumulation. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Shuichi Kishimoto, Nobuhito Fujitani, Takanori Ohnishi, Hiroki Aoki, Ryosuke Suzuki, Shoji Fukushima. Cisplatin-loaded, Sialyl Lewis X-Modified Liposomes: Drug Release, Biodistribution and Antitumor Efficacy. Anticancer research. 2017 Nov;37(11):6055-6061