Changes in the Lysosomal System of Cervical Cancer Cells Induced by Emodin Action.

Wojciech Trybus, Teodora Król, Ewa Trybus, Anna Kopacz-Bednarska, Grzegorz Król, Ewa Karpowicz

Anticancer research 2017 Nov

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An example of plant-derived compounds that may be of great importance in oncological therapy is emodin. The aim of this study was to evaluate the range of changes in the lysosomal compartment of HeLa cervical cancer cells treated with emodin. Changes in the lysosomal compartment were evaluated using microscopic techniques. In order to evaluate the activity of lysosomal enzymes and the permeability of the lysosomal membrane, a spectrophotometric technique was employed. Emodin induced significant changes in the lysosomal compartment, manifesting as an increase in the number of lysosomes, autophagic vacuoles and the activity of lysosomal hydrolases. Emodin exhibited cytotoxic activity against lysosomes through lysosomal membrane damage with possible leaks of lysosomal hydrolases into the cytoplasm. Emodin induces degradation processes and promotes the death of tumor cells through a mechanism that occurs with clear involvement of the lysosomal compartment. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Wojciech Trybus, Teodora Król, Ewa Trybus, Anna Kopacz-Bednarska, Grzegorz Król, Ewa Karpowicz. Changes in the Lysosomal System of Cervical Cancer Cells Induced by Emodin Action. Anticancer research. 2017 Nov;37(11):6087-6096