1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using thioglycosides.

1,3-Dibromo-5,5-dimethylhydantoin (DBDMH), an inexpensive, non-toxic and stable reagent, is a competent activator of thioglycosides for glycosidic bond formation. Excellent yields were obtained when triflic acid (TfOH) or trimethylsilyl trifluoromethanesulfonate (TMSOTf) were employed as co-promoters in solution or automated glycan assembly on solid phase.

Citation

Fei-Fei Xu, Claney L Pereira, Peter H Seeberger. 1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using thioglycosides. Beilstein journal of organic chemistry. 2017;13:1994-1998

PMID: 29062419

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