Quantitative target proteomics of chromosome 13 human blood plasma proteins.

A T Kopylov, E V Ilgisonis, O V Tikhonova, T E Farafonova, S E Novikova, V G Zgoda, E A Ponomarenko, A V Lisitsa, A A Markin, B V Morukov, A I Grigoriev, A I Archakov

Doklady. Biochemistry and biophysics 2017 Sep

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Quantitative proteomic analysis of 50 blood plasma samples of healthy volunteers who underwent a comprehensive medical examination and were found eligible for space flights was performed. As a result of directed mass spectrometric analysis, signals for 128 proteins, which accounted for nearly 40% of the total number of chromosome 13 gene products, were detected. The analysis of interindividual variation of concentrations of chromosome 13 proteins showed the presence of a pool comprising 41 proteins with a low variation (CV < 30%), which can potentially be used as biomarkers.

Citation

A T Kopylov, E V Ilgisonis, O V Tikhonova, T E Farafonova, S E Novikova, V G Zgoda, E A Ponomarenko, A V Lisitsa, A A Markin, B V Morukov, A I Grigoriev, A I Archakov. Quantitative target proteomics of chromosome 13 human blood plasma proteins. Doklady. Biochemistry and biophysics. 2017 Sep;476(1):326-328