Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species (Taxus spp.).

D V Kochkin, E B Globa, E V Demidova, V V Gaisinsky, B A Galishev, N G Kolotyrkina, Vl V Kuznetsov, A M Nosov

Doklady. Biochemistry and biophysics 2017 Sep

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This is the first study to show that the formation of 14β-hydroxylated derivatives of taxa-4(20),11-diene is a specific feature of in vitro cultured dedifferentiated yew cells that distinguishes them from intact plant cells. This may be due to a lower toxicity of the 14-OH taxoids for proliferating plant cells compared to the 13-OH derivatives.

Citation

D V Kochkin, E B Globa, E V Demidova, V V Gaisinsky, B A Galishev, N G Kolotyrkina, Vl V Kuznetsov, A M Nosov. Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species (Taxus spp.). Doklady. Biochemistry and biophysics. 2017 Sep;476(1):337-339