Regulation of genome-wide DNA methylation by mobile small RNAs.

Contents I. II. III. IV. V. VI. VII. VIII. IX. References SUMMARY: RNA-directed DNA methylation (RdDM) at cytosine residues regulates gene expression, silences transposable elements and influences genome stability. The mechanisms responsible for RdDM are guided to target loci by small RNAs (sRNAs) that can move within plants cell to cell and long distance. Here we discuss recent advances in the understanding of interactions between mobile sRNAs and DNA methylation. We describe the mechanisms of sRNA movement, the differences between known classes of mobile sRNA-DNA methylation interactions and the limits of current knowledge. Finally, we discuss potential applications of mobile sRNAs in modifying plant traits. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Citation

Muluneh Tamiru, Thomas J Hardcastle, Mathew G Lewsey. Regulation of genome-wide DNA methylation by mobile small RNAs. The New phytologist. 2017 Nov 06

PMID: 29105762

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