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Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria. Copyright © 2017. Published by Elsevier Inc.
Citation
Lilian Lamech, Cole M Haynes. Vms1 Relieves a Mitochondrial Import Chokehold. Developmental cell. 2017 Nov 06;43(3):259-260
PMID: 29112848
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