Hidden Secrets of Sigma54 Promoters Revealed.

Nan Hao, Keith E Shearwin

Trends in biochemical sciences 2017 Dec

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Bacterial sigma54 (σ54) promoters are the DNA-binding motif for σ54-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ54 promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Citation

Nan Hao, Keith E Shearwin. Hidden Secrets of Sigma54 Promoters Revealed. Trends in biochemical sciences. 2017 Dec;42(12):931-932

PMID: 29126750

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