Understanding the role of mammalian sterile 20-like kinase 1 (MST1) in cardiovascular disorders.

Hippo signaling is a conserved pathway and plays important role in controlling cell proliferation and differentiation. As critical components of the Hippo pathway in mammals, mammalian sterile 20-like kinase 1 (MST1) participate in cell apoptosis and cell proliferation. Yes-associated protein (YAP) acts as a downstream transcriptional co-activator of MST1. MST1 is present in heart tissue and helps determine the fate of cardiomyocytes by regulating the balance between autophagy and apoptosis. Recent studies showed MST1 signaling is an essential participant in many cardiovascular disorders, including aortic dissection, aortic aneurysm, atherosclerosis, myocardial ischemic injury, and cardiomyopathy. Previous studies have summarized the roles of MST1 in cardiovascular development. In this review, we focused on the role of MST1 signaling in cardiovascular disorders. Copyright © 2017. Published by Elsevier Ltd.

Citation

Yang Yang, Haichang Wang, Zhiqiang Ma, Wei Hu, Dongdong Sun. Understanding the role of mammalian sterile 20-like kinase 1 (MST1) in cardiovascular disorders. Journal of molecular and cellular cardiology. 2017 Nov 15

PMID: 29155025

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