Cu(OAc)2 /TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines.

A novel and efficient Cu(OAc)2 -catalyzed hydroamination cyclization and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidative dehydrogenation cascade reaction of homopropargylic amines has been developed. A library of 1,2-disubstituted pyrrole derivatives were obtained in good-to-high yields in one pot with no step-by-step feeding process. This reaction involved TEMPO playing dual roles as both an oxidative dehydrogenation reagent and a ligand. An insight into the reaction mechanism was obtained by using several analytical determination methods. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Yuanfang Kong, Kediliya Wumaier, Yingze Liu, Chunhui Jiang, Shuai Wang, Lingyan Liu, Weixing Chang, Jing Li. Cu(OAc)2 /TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines. Chemistry, an Asian journal. 2017 Nov 27

PMID: 29178594

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