Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins.

Jay C Dunlap, Jennifer J Loros

Molecular cell 2018 Jan 18

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Some longstanding dogmas in the circadian field warrant reexamination in light of recent studies focused on the role of post-translational modifications and intrinsic disorder in core circadian clock proteins of mice and fungi. Such dogmas include the role of turnover in circadian feedback loops and the origin myths describing evolutionary relatedness among circadian clocks. In this Essay, the authors recapitulate recent findings on circadian clock protein regulation by taking an unconventional approach in the form of a dialog between Wizard and Apprentice. Copyright © 2017 Elsevier Inc. All rights reserved.

Citation

Jay C Dunlap, Jennifer J Loros. Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins. Molecular cell. 2018 Jan 18;69(2):165-168