Non-polarized cytokine profile of a long-term non-progressor HIV infected patient.

The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles. Copyright © 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

Citation

Ana Flávia Pina, Vanessa Terezinha Gubert de Matos, Camila Mareti Bonin, Márcia Maria Ferrairo Janini Dal Fabbro, Inês Aparecida Tozetti. Non-polarized cytokine profile of a long-term non-progressor HIV infected patient. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. 2018 Mar - Apr;22(2):142-145

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PMID: 29476708

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