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Objective: To evaluate the role of the adrenergic receptor alpha-2A gene (ADRA2A) in the genetic etiology of ADHD comorbid with tic disorders (ADHD+TD). Method: Two single nucleotide polymorphisms (SNPs) of ADRA2A were genotyped and analyzed in 936 normal controls and 1,815 ADHD probands, including 1,249 trios. Approximately 16% of the ADHD probands also had a diagnosis of TD. Results: No significant association was found between ADRA2A and ADHD in general. Case-control analyses indicated different allelic and genotypic distributions of rs553668 between ADHD+TD and controls in males. Family-based association tests showed that the G allele of rs1800544, the A allele of rs553668, and the GA haplotype consisting of these two SNPs were overtransmitted in the ADHD+TD trios, especially in males. Moreover, the allelic/genotypic distribution and allelic transmission were different between ADHD+TD and ADHD without TD. Conclusion: ADRA2A may be associated with ADHD+TD, especially in males.


Defeng Xu, Lu Liu, Haimei Li, Li Sun, Li Yang, Qiujin Qian, Yufeng Wang. Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders. Journal of attention disorders. 2021 Jan;25(1):33-43

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PMID: 29482474

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