Nazario D Rivera-Chaparro, Jessica Ericson, Huali Wu, P Brian Smith, Reese H Clark, Daniel K Benjamin, Michael Cohen-Wolkowiez, Rachel G Greenberg
The Pediatric infectious disease journal 2019 FebMicafungin is used off-label in the United States to treat invasive candidiasis in neonates. We used an established pharmacokinetic model to determine micafungin exposures for 46 courses in 39 hospitalized infants. In this small cohort of infants, micafungin exposure was not associated with laboratory markers of liver toxicity, death or failure of microbiologic clearance.
Nazario D Rivera-Chaparro, Jessica Ericson, Huali Wu, P Brian Smith, Reese H Clark, Daniel K Benjamin, Michael Cohen-Wolkowiez, Rachel G Greenberg. Safety, Effectiveness and Exposure-response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records. The Pediatric infectious disease journal. 2019 Feb;38(2):e26-e28
PMID: 29601453
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