Protective effect of miR378* on doxorubicin-induced cardiomyocyte injury via calumenin.

Doxorubicin (Dox) is a highly effective antitumor antibiotic, however myocardial toxicity severely limits its use clinically. The pathogenesis of doxorubicin-induced cardiomyopathy is unclear. In Dox cardiomyopathy mice, there is a decline in cardiac function, a change in myocardial pathology and a reduction in miR378* expression. Expression changes in calumenin, an endoplasmic reticulum stress (ERS) chaperone protein and pathway factor, as well as apoptosis, were observed in cardiomyocytes after doxorubicin-induced injury. However, miR378* increased calumenin expression, eased ERS, and reduced cardiomyocyte apoptosis, while, silencing miR378* reduced calumenin expression, aggravated ERS, and increased cardiomyocyte apoptosis. The above results indicate that miR378* alleviates ERS and inhibits the activation of the ERS-mediated apoptosis signaling pathway in cardiomyocytes via regulating calumenin expression, thereby reducing cardiomyocyte apoptosis after doxorubicin-induced injury. Increasing miR378* expression may be a new way to improve cardiac function and quality of life in patients with Dox cardiomyopathy. © 2018 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

Citation

Yu Wang, Xiaoxue Cui, Yilin Wang, Yao Fu, Xin Guo, Jie Long, Chengxi Wei, Ming Zhao. Protective effect of miR378* on doxorubicin-induced cardiomyocyte injury via calumenin. Journal of cellular physiology. 2018 Oct;233(10):6344-6351

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PMID: 29665007

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