Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle.

Makoto Kondo, Aya Noguchi, Yuki Matsuura, Masumi Shimada, Naoto Yokota, Hiroyuki Kawahara

Biochemical and biophysical research communications 2018 Jun 22

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The ZFP36 family is a prototypical member of a highly conserved group of proteins with CCCH-type RNA-binding domains, whose functional role and regulatory mechanism in mitotic cells remain obscure. In this study, we provide the first evidence that ZFP36L1 phosphorylation is modulated in a cell cycle-dependent manner. The C-terminal region of ZFP36L1 is critical for its cell cycle-dependent phosphorylation of this protein. We also suggest that the phosphorelay-dependent regulation of ZFP36L1 influences mitotic spindle organization. Thus, our data demonstrate a new class of regulatory mechanism for CCCH-type zinc-finger proteins in cell cycle control. Copyright © 2018 Elsevier Inc. All rights reserved.

Citation

Makoto Kondo, Aya Noguchi, Yuki Matsuura, Masumi Shimada, Naoto Yokota, Hiroyuki Kawahara. Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle. Biochemical and biophysical research communications. 2018 Jun 22;501(2):387-393