Idiopathic teratozoospermia is not correlated with c.144delC polymorphism in the AURKC gene in Sichuan].

Xue-Mei Mu, Fang-Ying Cui, Zhuo Zhang, Xian-Ping Ding

Zhonghua nan ke xue = National journal of andrology 2017 Dec

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To investigate the association of a very common mutation of c.144delC in the aurora kinase C (AURKC) gene with idiopathic teratozoospermia in Chinese infertile men in Sichuan. Using polymerase chain reaction (PCR) and next-generation sequencing, we analyzed the correlation between c.144delC polymorphism of the AURKC gene and male infertility in 98 idiopathic teratozoospermia patients in comparison with 162 normal fertile men. Neither c.144delC mutation nor other meaningful mutations were detected in the AURKC gene in the 98 idiopathic teratozoospermia patients or the 162 normal controls. Teratozoospermia is not correlated with c.144delC mutation in the AURKC gene in the men of the Sichuan area. Therefore, large-scale genotyping of the AURKC gene may not be necessary clinically among Chinese patients with idiopathic teratozoospermia.

Citation

Xue-Mei Mu, Fang-Ying Cui, Zhuo Zhang, Xian-Ping Ding. Idiopathic teratozoospermia is not correlated with c.144delC polymorphism in the AURKC gene in Sichuan]. Zhonghua nan ke xue = National journal of andrology. 2017 Dec;23(12):1069-1074